ABSTRACT
En el presente trabajo se investigó si existe en el duodeno de rata alguna sustancia con efecto sobre el desarrollo del carcinosarcoma de Walter, que seria la responsable del diferente comportamiento fisiopatológico de este tejido frente a las celulas neoplásicas. Después de evidenciar la presencia de ese factor actividad antitumoral, se determimino sus propiedades farmacológicas y químicas y se estudio su presencia en distintas secciones del tracto gastrointestinal y en otros tejidos del mismo animal y en tejido duodenal de otras especies
Subject(s)
Mice , Rats , Animals , Duodenal Neoplasms/ultrastructure , Ethanol/antagonists & inhibitors , Indicators and Reagents/antagonists & inhibitors , Animals, Laboratory , Duodenum/analysisSubject(s)
Adolescent , Adult , Aged , Cholecystokinin/analysis , Chronic Disease , Duodenum/analysis , Female , Humans , Male , Middle Aged , Pancreatic Diseases/metabolism , Pancreatic Neoplasms/analysis , Secretin/analysis , ThailandABSTRACT
Histamine content of the digestive tract of a catfish Clarias batrachus has been estimated biologically on the atropinized guineapig ileum. A significant decrease of histamine content has been observed with the decrease of gonosomatic index (G.S.I.) during breeding season in female fishes, while no such type of change in histamine content of male fishes during breeding season has been noted. In the summer histamine content of both the sexes was signivicantly lowered in comparison with the histamine content during breeding season in both the sexes. It is concluded that higher histamine content in prespawing female fishes during breeding season may be due to the inhibition of the enzyme histaminase by gonadotrophines. It is also suggested that the route of inactivation of histamine during breeding season may be different in both the sexes, while in summer a common factor may be involved in depletion of histamine content of both the sexes.